Pub. Date : 2007 Jul
PMID : 17538395
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We assessed the bone marrow uptake of (99m)Tc-MIBI and its correlation with messenger RNA (mRNA) levels of MDR1, multidrug-resistance associated protein-1 (MRP1) and lung resistance protein (LRP) in acute leukaemia. | Technetium Tc 99m Sestamibi | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | RESULTS: There was an inverse relationship between (99m)Tc-MIBI uptake of bone marrow and both mRNA levels of MDR1 and MRP1 (P=0.000, r= -0.733 and P=0.001, r= -0.610, respectively). | Technetium Tc 99m Sestamibi | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | CONCLUSION: Increased expression of MDR1 and MRP1 correlates with a low accumulation of (99m)Tc-MIBI in bone marrow areas in patients with acute leukaemia. | Technetium Tc 99m Sestamibi | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | (99m)Tc-MIBI bone marrow scintigraphy can identify the MDR1 and MRP1 phenotype, but not LRP, in patients with acute leukaemia. | Technetium Tc 99m Sestamibi | ATP binding cassette subfamily B member 1 | Homo sapiens |