Pub. Date : 2007 Aug
PMID : 17538024
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mechanistically, we show that the recruitment of the ERM-interacting Rho/Cdc42-specific guanine nucleotide exchange factor Dbl to the plasma membrane and to lipid raft microdomains requires the phosphorylated, active conformer of ezrin, which serves to tether the plasma membrane or its subdomains to the cytoskeleton. | Guanine Nucleotides | MCF.2 cell line derived transforming sequence | Homo sapiens |
| 2 | Together these data suggest a mechanism whereby precise spatial guanine nucleotide exchange of Cdc42 by Dbl is dependent on functional ERM proteins and is important for directional cell migration. | Guanine Nucleotides | MCF.2 cell line derived transforming sequence | Homo sapiens |