Title : Modulation of ADP-induced platelet activation by aspirin and pravastatin: role of lectin-like oxidized low-density lipoprotein receptor-1, nitric oxide, oxidative stress, and inside-out integrin signaling.

Pub. Date : 2007 Sep

PMID : 17538005






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In this study, we investigated the effect of aspirin and pravastatin on LOX-1 expression on plate-lets. Aspirin oxidized low density lipoprotein receptor 1 Homo sapiens
2 In other experiments, treatment with aspirin (1-10 mM) and pravastatin (1-5 microM) reduced platelet LOX-1 expression, with a synergistic effect of the combination of aspirin and pravastatin. Aspirin oxidized low density lipoprotein receptor 1 Homo sapiens
3 In other experiments, treatment with aspirin (1-10 mM) and pravastatin (1-5 microM) reduced platelet LOX-1 expression, with a synergistic effect of the combination of aspirin and pravastatin. Aspirin oxidized low density lipoprotein receptor 1 Homo sapiens
4 Furthermore, aspirin and pravastatin inhibit LOX-1 expression on platelets in part by favorably affecting ROS and NO release from activated platelets. Aspirin oxidized low density lipoprotein receptor 1 Homo sapiens