Title : Apoptotic action of peroxisome proliferator-activated receptor-gamma activation in human non small-cell lung cancer is mediated via proline oxidase-induced reactive oxygen species formation.

Pub. Date : 2007 Sep

PMID : 17535976






10 Functional Relationships(s)
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1 Apoptotic action of peroxisome proliferator-activated receptor-gamma activation in human non small-cell lung cancer is mediated via proline oxidase-induced reactive oxygen species formation. Reactive Oxygen Species proline dehydrogenase 1 Homo sapiens
2 Reactive oxygen species (ROS) production was accompanied by increased expression of proline oxidase (POX), a redox enzyme expressed in mitochondria, upon incubation with the agonists. Reactive Oxygen Species proline dehydrogenase 1 Homo sapiens
3 Reactive oxygen species (ROS) production was accompanied by increased expression of proline oxidase (POX), a redox enzyme expressed in mitochondria, upon incubation with the agonists. Reactive Oxygen Species proline dehydrogenase 1 Homo sapiens
4 Reactive oxygen species (ROS) production was accompanied by increased expression of proline oxidase (POX), a redox enzyme expressed in mitochondria, upon incubation with the agonists. Reactive Oxygen Species proline dehydrogenase 1 Homo sapiens
5 Reactive oxygen species (ROS) production was accompanied by increased expression of proline oxidase (POX), a redox enzyme expressed in mitochondria, upon incubation with the agonists. Reactive Oxygen Species proline dehydrogenase 1 Homo sapiens
6 POX RNA interference treatment blocked PPARgamma-induced ROS formation and cytotoxicity, suggesting that POX plays a functional role in apoptosis through ROS formation. Reactive Oxygen Species proline dehydrogenase 1 Homo sapiens
7 POX RNA interference treatment blocked PPARgamma-induced ROS formation and cytotoxicity, suggesting that POX plays a functional role in apoptosis through ROS formation. Reactive Oxygen Species proline dehydrogenase 1 Homo sapiens
8 POX RNA interference treatment blocked PPARgamma-induced ROS formation and cytotoxicity, suggesting that POX plays a functional role in apoptosis through ROS formation. Reactive Oxygen Species proline dehydrogenase 1 Homo sapiens
9 POX RNA interference treatment blocked PPARgamma-induced ROS formation and cytotoxicity, suggesting that POX plays a functional role in apoptosis through ROS formation. Reactive Oxygen Species proline dehydrogenase 1 Homo sapiens
10 The results of the present study suggest that PPARgamma activation induces apoptotic cell death in non-small-cell lung carcinoma mainly through ROS formation via POX induction. Reactive Oxygen Species proline dehydrogenase 1 Homo sapiens