Title : Associations of ABCB1, ABCC2, and ABCG2 polymorphisms with irinotecan-pharmacokinetics and clinical outcome in patients with advanced non-small cell lung cancer.

Pub. Date : 2007 Jul 1

PMID : 17534875






2 Functional Relationships(s)
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Protein Name
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1 Associations of ABCB1, ABCC2, and ABCG2 polymorphisms with irinotecan-pharmacokinetics and clinical outcome in patients with advanced non-small cell lung cancer. Irinotecan ATP binding cassette subfamily B member 1 Homo sapiens
2 CONCLUSIONS: Specific polymorphisms of ABCB1 and ABCC2 can influence disposition and tumor response to irinotecan by regulating transporter activity. Irinotecan ATP binding cassette subfamily B member 1 Homo sapiens