Title : Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA(1), p42 and p38alpha.

Pub. Date : 2007 Jul

PMID : 17531530






3 Functional Relationships(s)
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1 We report here that lysophosphatidic acid (LPA), a potent bioactive phospholipid, induces prostate cancer PC3 cell migration via the activation of the LPA(1) receptor, which is linked to a PTX-sensitive activation mechanism of the mitogen-activated protein kinases (MAPK). lysophosphatidic acid mitogen-activated protein kinase 3 Homo sapiens
2 We report here that lysophosphatidic acid (LPA), a potent bioactive phospholipid, induces prostate cancer PC3 cell migration via the activation of the LPA(1) receptor, which is linked to a PTX-sensitive activation mechanism of the mitogen-activated protein kinases (MAPK). lysophosphatidic acid mitogen-activated protein kinase 3 Homo sapiens
3 Our results demonstrate that parallel activation of ERK1/2 and p38, but not JNK, is responsible for LPA-stimulated PC3 cell migration. lysophosphatidic acid mitogen-activated protein kinase 3 Homo sapiens