Pub. Date : 2007 Nov-Dec
PMID : 17531350
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hydrogen peroxide attenuates insulin-like growth factor-1 neuroprotective effect, prevented by minocycline. | Hydrogen Peroxide | insulin like growth factor 1 | Homo sapiens |
| 2 | We now report that sublethal doses of hydrogen peroxide attenuated IGF-1 neuroprotective activity on cultured cerebellar granule neurons under potassium and serum deprivation. | Hydrogen Peroxide | insulin like growth factor 1 | Homo sapiens |
| 3 | Furthermore, hydrogen peroxide also blocked IGF-1"s neuroprotection for cortical neurons deprived of neurotrophic factors (B27), which was prevented by minocycline. | Hydrogen Peroxide | insulin like growth factor 1 | Homo sapiens |
| 4 | Our data suggest that inhibition of IGF-1 signaling by hydrogen peroxide may constitute an additional pathway contributing to its neurotoxicity. | Hydrogen Peroxide | insulin like growth factor 1 | Homo sapiens |