Title : CYP3A4 activity in the presence of organic cosolvents, ionic liquids, or water-immiscible organic solvents.

Pub. Date : 2007 Jul 9

PMID : 17526062






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We show that CYP3A4 tolerates only small amounts (<15 %) of water-miscible organic cosolvents or ionic liquids before its activity toward testosterone drops below detection. Testosterone cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 CYP3A4 activity in the absence of buffer was only >or=10 % in solvents of the alkane series, with a minimum of 0.85 % water, and with the addition of sucrose and testosterone before enzyme lyophilization. Testosterone cytochrome P450 family 3 subfamily A member 4 Homo sapiens