Title : Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4.

Pub. Date : 2007 Jul

PMID : 17523162






6 Functional Relationships(s)
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1 The efflux of phospholipids from HEK/ABCB4 cells was remarkably increased by the addition of taurocholate. Taurocholic Acid ATP binding cassette subfamily B member 4 Homo sapiens
2 In addition, the cholesterol efflux from HEK/ABCB4 cells was also enhanced in the presence of taurocholate. Taurocholic Acid ATP binding cassette subfamily B member 4 Homo sapiens
3 Light scattering measurements suggested that the taurocholate monomer plays an important role in ABCB4-mediated lipid secretion. Taurocholic Acid ATP binding cassette subfamily B member 4 Homo sapiens
4 Taurocholate promoted the efflux of phospholipids and cholesterol from HEK/ABCB4 cells more efficiently than glycocholate and cholate. Taurocholic Acid ATP binding cassette subfamily B member 4 Homo sapiens
5 Verapamil completely inhibited the taurocholate-dependent efflux of phospholipids and cholesterol from HEK/ABCB4 cells. Taurocholic Acid ATP binding cassette subfamily B member 4 Homo sapiens
6 Mass spectrometry revealed that, in the presence of taurocholate, HEK/ABCB4 cells preferentially secreted PC compared to sphingomyelin. Taurocholic Acid ATP binding cassette subfamily B member 4 Homo sapiens