Pub. Date : 1991
PMID : 1751755
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Both phenobarbital and tryptophan increased tryptophan 2,3-dioxygenase activity (total enzyme and holoenzyme) but had different effects on the rate of activation and the degree of saturation of the enzyme with haem. | Phenobarbital | tryptophan 2,3-dioxygenase | Rattus norvegicus |
| 2 | It is proposed that combined administration of phenobarbital and tryptophan leads to substrate stabilisation of tryptophan 2,3-dioxygenase, and that this is accompanied by the binding of the newly synthesised haem, thus making haem unavailable for formation of cytochrome P-450. | Phenobarbital | tryptophan 2,3-dioxygenase | Rattus norvegicus |