Title : P-glycoprotein mediates celecoxib-induced apoptosis in multiple drug-resistant cell lines.

Pub. Date : 2007 May 15

PMID : 17510421






1 Functional Relationships(s)
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1 We found that 10 micromol/L celecoxib reduced P-glycoprotein, Bcl-x(L), and Bcl-2 expression, and induced translocation of Bax from cytosol to mitochondria and cytochrome c release into cytosol in MDR-positive hepatocellular carcinoma cells. Celecoxib BCL2 associated X, apoptosis regulator Homo sapiens