Title : Aspirin blocks proliferation in colon cells by inducing a G1 arrest and apoptosis through activation of the checkpoint kinase ATM.

Pub. Date : 2007 Oct

PMID : 17510082






1 Functional Relationships(s)
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1 Aspirin induced the phosphorylation of p53 at residue Ser15 within 8 h in a caffeine-dependent manner, and also caused the activation of checkpoint kinase 2 and the cleavage of caspase 7. Caffeine tumor protein p53 Homo sapiens