Title : The effect of quercetin phase II metabolism on its MRP1 and MRP2 inhibiting potential.

Pub. Date : 2007 Jul 15

PMID : 17509533






2 Functional Relationships(s)
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1 The present study characterises the effect of phase II metabolism, especially methylation and glucuronidation, of the model flavonoid quercetin on its capacity to inhibit human MRP1 and MRP2 activity in Sf9 inside-out vesicles. Flavonoids ATP binding cassette subfamily C member 1 Homo sapiens
2 This finding indicates that phase II metabolism of quercetin could enhance the potential use of quercetin- or flavonoids in general-as an inhibitor to overcome MRP-mediated multidrug resistance. Flavonoids ATP binding cassette subfamily C member 1 Homo sapiens