Pub. Date : 2007 Jul 15
PMID : 17509533
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effect of quercetin phase II metabolism on its MRP1 and MRP2 inhibiting potential. | Quercetin | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 2 | The present study characterises the effect of phase II metabolism, especially methylation and glucuronidation, of the model flavonoid quercetin on its capacity to inhibit human MRP1 and MRP2 activity in Sf9 inside-out vesicles. | Quercetin | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 3 | Overall, the results of this study reveal that the major phase II metabolites of quercetin are equally potent or even better inhibitors of human MRP1 and MRP2 than quercetin itself. | Quercetin | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 4 | This finding indicates that phase II metabolism of quercetin could enhance the potential use of quercetin- or flavonoids in general-as an inhibitor to overcome MRP-mediated multidrug resistance. | Quercetin | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 5 | This finding indicates that phase II metabolism of quercetin could enhance the potential use of quercetin- or flavonoids in general-as an inhibitor to overcome MRP-mediated multidrug resistance. | Quercetin | ATP binding cassette subfamily C member 1 | Homo sapiens |