Title : Altered thyroidal responsivity to thyrotropin induced by circulating thyroid hormones. A "short-loop" regulatory mechanism?

Pub. Date : 1976 Mar

PMID : 175094






2 Functional Relationships(s)
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1 In the rat both L-thyroxine (T4) and 3,5,3"-L-triiodothyronine (T3) pretreatment inhibited TSH-induced thyroidal ornithine decarboxylase (ODC) activity in vivo in a dose-related manner (half-maximal inhibition, 1.7 mug/rat and 0.6 mug/rat, respectively). Triiodothyronine ornithine decarboxylase 1 Rattus norvegicus
2 In the rat both L-thyroxine (T4) and 3,5,3"-L-triiodothyronine (T3) pretreatment inhibited TSH-induced thyroidal ornithine decarboxylase (ODC) activity in vivo in a dose-related manner (half-maximal inhibition, 1.7 mug/rat and 0.6 mug/rat, respectively). Triiodothyronine ornithine decarboxylase 1 Rattus norvegicus