Title : Angiotensin II Type 1 receptor antagonism mediates uncoupling protein 2-driven oxidative stress and ameliorates pancreatic islet beta-cell function in young Type 2 diabetic mice.

Pub. Date : 2007 Jul

PMID : 17508912






1 Functional Relationships(s)
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1 Losartan selectively inhibited oxidative stress via downregulation of NADPH oxidase; this in turn suppressed UCP2 expression, thus improving beta-cell insulin secretion and decreasing apoptosis-induced beta-cell mass loss in db/db mouse islets. Losartan uncoupling protein 2 (mitochondrial, proton carrier) Mus musculus