Title : beta-Actin regulates platelet nitric oxide synthase 3 activity through interaction with heat shock protein 90.

Pub. Date : 2007 May 22

PMID : 17502619






1 Functional Relationships(s)
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1 Formation of this ternary complex among NOS-3, globular beta-actin, and Hsp90, in turn, results in an increase in both NOS activity and cyclic guanosine-3",5"-monophosphate, an index of bioactive NO, as well as an increased rate of Hsp90 degradation, thus limiting the duration for which NOS-3 remains activated. Cyclic GMP nitric oxide synthase 3 Homo sapiens