Title : A role for exposed mannosylations in presentation of human therapeutic self-proteins to CD4+ T lymphocytes.

Pub. Date : 2007 May 22

PMID : 17502612






4 Functional Relationships(s)
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1 We demonstrate that entry of FVIII into human dendritic cells (DC) leading to T cell activation, is mediated by mannose-terminating glycans on FVIII. Mannose coagulation factor VIII Homo sapiens
2 We demonstrate that entry of FVIII into human dendritic cells (DC) leading to T cell activation, is mediated by mannose-terminating glycans on FVIII. Mannose coagulation factor VIII Homo sapiens
3 The interaction between FVIII and CD206 was blocked by VWF, suggesting that, under physiological conditions, the intrinsic mannose-dependent immunogenicity of FVIII is quenched by endogenous immunochaperones. Mannose coagulation factor VIII Homo sapiens
4 The interaction between FVIII and CD206 was blocked by VWF, suggesting that, under physiological conditions, the intrinsic mannose-dependent immunogenicity of FVIII is quenched by endogenous immunochaperones. Mannose coagulation factor VIII Homo sapiens