Title : Characterization of heme as activator of Toll-like receptor 4.

Pub. Date : 2007 Jul 13

PMID : 17502383






1 Functional Relationships(s)
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1 Signaling of heme through TLR4 depended on an interaction distinct from the one established between TLR4 and lipopolysaccharide (LPS) since anti-TLR4/MD2 antibody or a lipid A antagonist inhibited LPS-induced TNF-alpha secretion but not heme activity. Lipid A toll like receptor 4 Homo sapiens