Pub. Date : 2007 Jun
PMID : 17499749
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TNF-alpha modulates hepatic Na+-K+ ATPase activity via PGE2 and EP2 receptors. | Dinoprostone | tumor necrosis factor | Homo sapiens |
| 2 | This effect disappeared in presence of indomethacin, an inhibitor of COX enzymes, and PGE2 injected to the animals imitated the effect of TNF-alpha. | Dinoprostone | tumor necrosis factor | Homo sapiens |
| 3 | It was concluded that TNF-alpha induces in hepatocytes, PGE2 production which in turn reduces the activity and protein expression of the Na(+)-K(+) ATPase by activating EP2 receptors. | Dinoprostone | tumor necrosis factor | Homo sapiens |