Title : P-glycoprotein in proteoliposomes with low residual detergent: the effects of cholesterol.

Pub. Date : 2007 Nov

PMID : 17497080






2 Functional Relationships(s)
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1 CONCLUSIONS: Cholesterol influences P-gp in three ways: (a) it enhances its basal ATPase activity, (b) it renders P-gp sensitive towards the modulators verapamil and progesterone and (c) it affects the modulator concentration at half maximal ATPase activation. Progesterone ATP binding cassette subfamily B member 1 Homo sapiens
2 CONCLUSIONS: Cholesterol influences P-gp in three ways: (a) it enhances its basal ATPase activity, (b) it renders P-gp sensitive towards the modulators verapamil and progesterone and (c) it affects the modulator concentration at half maximal ATPase activation. Progesterone ATP binding cassette subfamily B member 1 Homo sapiens