Pub. Date : 2008 Jan
PMID : 17495874
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Contribution of itraconazole metabolites to inhibition of CYP3A4 in vivo. | Itraconazole | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | A 3.9-fold decrease in the hepatic intrinsic clearance of a CYP3A4 substrate was predicted using the average unbound steady-state concentrations (C(ss,ave,u)) and liver microsomal inhibition constants for ITZ, OH-ITZ, keto-ITZ, and ND-ITZ. | Itraconazole | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Accounting for circulating metabolites of ITZ significantly improved the in vitro to in vivo extrapolation of CYP3A4 inhibition compared to a consideration of ITZ exposure alone. | Itraconazole | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |