Title : Effect of ion suppression on judgment of enzyme inhibition and avoidance of error by utilizing a stable isotope-labeled probe substrate: example of CYP3A4 inhibition with [13C4,15N] labeled midazolam as a substrate.

Pub. Date : 2007 Apr

PMID : 17495418






1 Functional Relationships(s)
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1 In this study, we have shown the ion suppression of 1"-hydroxymidazolam (analyte) and dextrorphan (IS) by erythromycin, as an example, which may cause over- or underestimation of CYP3A4 inhibition. 1-hydroxymethylmidazolam cytochrome P450 family 3 subfamily A member 4 Homo sapiens