Title : Determinants of growth hormone receptor down-regulation.

Pub. Date : 2007 Jul

PMID : 17488973






1 Functional Relationships(s)
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1 We found that JAK2"s ability to protect mature GHR from rapid degradation measured in the presence of the protein synthesis inhibitor, cycloheximide, depended on the presence of GHR"s Box 1 element and the intact JAK2 FERM (band 4.1/Ezrin/Radixin/Moesin); domain, but not the kinase-like or kinase domains of JAK2. Cycloheximide Janus kinase 2 Homo sapiens