Title : Mechanisms of discrimination between cobalamins and their natural analogues during their binding to the specific B12-transporting proteins.

Pub. Date : 2007 May 29

PMID : 17487979






1 Functional Relationships(s)
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Protein Name
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1 Three proteins, intrinsic factor (IF), transcobalamin (TC), and haptocorrin (HC), all have an extremely high affinity for the cobalamins (Cbls, Kd approximately 5 fM) but discriminate these physiological ligands from Cbl analogues with different efficiencies decreasing in the following order: IF > TC > HC. Vitamin B 12 Cbl proto-oncogene Homo sapiens