Title : Inhibition of the SH3 domain-mediated binding of Src to the androgen receptor and its effect on tumor growth.

Pub. Date : 2007 Oct 11

PMID : 17486077






1 Functional Relationships(s)
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1 Treatment of the human prostate or mammary cancer cells (LNCaP or MCF-7, respectively) with nanomolar concentrations of this peptide inhibits the androgen- or estradiol-induced association between the AR or the ER and Src the Src/Erk pathway activation, cyclin D1 expression and DNA synthesis, without interfering in the receptor-dependent transcriptional activity. Estradiol cyclin D1 Homo sapiens