Pub. Date : 2007 May 1
PMID : 17483362
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We examined whether PTEN deficiency leads to radioresistance and whether this can be reversed by nelfinavir, a protease inhibitor that decreases Akt signaling. | Nelfinavir | AKT serine/threonine kinase 1 | Homo sapiens |
2 | Nelfinavir decreased Akt phosphorylation and enhanced radiosensitization in U251MG and U87MG glioblastoma cells, both of which are PTEN deficient. | Nelfinavir | AKT serine/threonine kinase 1 | Homo sapiens |
3 | This epistasis-type analysis suggests that the nelfinavir acts along the Akt pathway to radiosensitize cells. | Nelfinavir | AKT serine/threonine kinase 1 | Homo sapiens |