Title : Phosphatase and tensin homologue deficiency in glioblastoma confers resistance to radiation and temozolomide that is reversed by the protease inhibitor nelfinavir.

Pub. Date : 2007 May 1

PMID : 17483362






3 Functional Relationships(s)
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1 We examined whether PTEN deficiency leads to radioresistance and whether this can be reversed by nelfinavir, a protease inhibitor that decreases Akt signaling. Nelfinavir AKT serine/threonine kinase 1 Homo sapiens
2 Nelfinavir decreased Akt phosphorylation and enhanced radiosensitization in U251MG and U87MG glioblastoma cells, both of which are PTEN deficient. Nelfinavir AKT serine/threonine kinase 1 Homo sapiens
3 This epistasis-type analysis suggests that the nelfinavir acts along the Akt pathway to radiosensitize cells. Nelfinavir AKT serine/threonine kinase 1 Homo sapiens