Pub. Date : 2007 Aug
PMID : 17478558
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Differential 3,5,3"-triiodothyronine-mediated regulation of uncoupling protein 3 transcription: role of Fatty acids. | Triiodothyronine | uncoupling protein 3 | Rattus norvegicus |
| 2 | Within 8 h of single-dose T(3) administration, hypothyroid rats showed a rise in serum fatty acid levels concomitant with a rapid increase in UCP3 expression in gastrocnemius muscle, followed by inductions of peroxisome proliferator activated receptor delta (PPARdelta) (within 24 h) and PPAR target gene expression (after 24 h). | Triiodothyronine | uncoupling protein 3 | Rattus norvegicus |
| 3 | This T(3)-induced early UCP3 expression depended on fatty acid-PPAR signaling because depleting serum fatty acid levels abolished its expression, restorable by administration of the PPARdelta agonist L165,041 (4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]acetic acid). | Triiodothyronine | uncoupling protein 3 | Rattus norvegicus |