Title : Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products.

Pub. Date : 2007 Jun 30

PMID : 17475222






1 Functional Relationships(s)
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1 The apoptosis induced by guggulsterone was also indicated by the activation of caspase-8, bid cleavage, cytochrome c release, caspase-9 activation, caspase-3 activation, and PARP cleavage. pregna-4,17-diene-3,16-dione caspase 3 Homo sapiens