Title : Sequential recruitment of PCAF and BRG1 contributes to myogenin activation in 12-O-tetradecanoylphorbol-13-acetate-induced early differentiation of rhabdomyosarcoma-derived cells.

Pub. Date : 2007 Jun 29

PMID : 17468105






2 Functional Relationships(s)
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1 In addition, we have found that the p38 mitogen-activated protein kinase is required for BRG1 recruitment in TPA-mediated myogenin induction. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 14 Homo sapiens
2 We propose that there are two distinct activation steps for the induction of myogenin in TPA-induced early differentiation of RD cells: 1) an early step that requires PCAF activity to acetylate core histones and MyoD to initiate myogenin gene expression, and 2) a later step that requires p38-dependent activity of the SWI/SNF remodeling complex to provide an open conformation for the induction of myogenin. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 14 Homo sapiens