Title : Homologous desensitization of signalling by the alpha (alpha) isoform of the human thromboxane A2 receptor: a specific role for nitric oxide signalling.

Pub. Date : 2007 Jun

PMID : 17466390






1 Functional Relationships(s)
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1 Desensitization was impaired by the nitric oxide synthase (NOS), soluble guanylyl cyclase (sGC) and PKG inhibitors L-NAME, LY 83583 and KT5823, respectively, indicating that homologous desensitization of TP alpha involves nitric oxide generation and signalling. NG-Nitroarginine Methyl Ester protein kinase cGMP-dependent 1 Homo sapiens