Title : Distinct steps of cross-linking, self-association, and maturation of tropoelastin are necessary for elastic fiber formation.

Pub. Date : 2007 Jun 8

PMID : 17459412






1 Functional Relationships(s)
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1 Our data show that a C-terminal half-fragment of tropoelastin encoded by exons 16-36 (BH) is deposited onto microfibrils, yet we detect very limited amounts of the cross-linking amino acid, desmosine, an indicator of maturation, whereas the N-terminal half-fragment encoded by exons 2-15 (FH) was deficient for both deposition and cross-linking, suggesting that elastic fiber formation requires full-length tropoelastin molecules. Desmosine elastin Homo sapiens