Title : Pharmacological inhibition of RhoA signaling prevents connective tissue growth factor induction in endothelial cells exposed to non-uniform shear stress.

Pub. Date : 2008 Jan

PMID : 17452038






1 Functional Relationships(s)
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1 CTGF upregulation by non-uniform shear stress was RhoA-dependent, because it was almost completely inhibited in cells transfected with dominant negative RhoA-N19, and when cells were treated with 1 micromol/L simvastatin during flow. Simvastatin ras homolog family member A Homo sapiens