Title : RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation.

Pub. Date : 2007 Jun 8

PMID : 17449468






1 Functional Relationships(s)
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Protein Name
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1 The NZF domains of TAB2/3 are critical for TAB2/3 to bind to Lys(63)-linked polyubiquitin chains of other adaptor proteins, such as receptor-interacting protein and TRAF6, which are two signaling proteins essential for TNF- and IL-1-induced NF-kappaB activation, respectively. Lysine interleukin 1 alpha Homo sapiens