Title : Carbamazepine prevents breakdown of neurotransmitter release induced by hyperactivation of ryanodine receptor.

Pub. Date : 2007 Jun

PMID : 17445842






2 Functional Relationships(s)
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1 To clarify the mechanisms of the pharmacological action of carbamazepine (CBZ), we determined the effect of CBZ on GABA and glutamate release associated with the ryanodine receptor (Ryr)-sensitive Ca(2+)-induced Ca(2+)-releasing system (CICR) in the rat hippocampus using microdialysis. gamma-Aminobutyric Acid ryanodine receptor 2 Rattus norvegicus
2 To clarify the mechanisms of the pharmacological action of carbamazepine (CBZ), we determined the effect of CBZ on GABA and glutamate release associated with the ryanodine receptor (Ryr)-sensitive Ca(2+)-induced Ca(2+)-releasing system (CICR) in the rat hippocampus using microdialysis. gamma-Aminobutyric Acid ryanodine receptor 2 Rattus norvegicus