Title : 13C enrichment of carbons 2 and 8 of purine by folate-dependent reactions after [13C]formate and [2-13C]glycine dosing in adult humans.

Pub. Date : 2007 May

PMID : 17445548






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The 10-formyl moiety of 10-formyltetrahydrofolate is the source of carbons at the positions 8 (C(8)) and 2 (C(2)) of the purine ring, originating from formate and a few amino acids. formic acid complement C2 Homo sapiens
2 In adult humans, we independently measured the (13)C enrichment of the C(2) and C(8) positions of urinary uric acid after an oral dose of [(13)C]sodium formate and that of the C(2) and C(8) plus C(5) positions after [2-(13)C]glycine. formic acid complement C2 Homo sapiens
3 To our knowledge, this is the first study to investigate (13)C enrichment from formate and glycine independently into the C(2) and C(8) positions of purine in the same subjects. formic acid complement C2 Homo sapiens