Title : Differential association of phosphatidylinositol 3-kinase, SHIP-1, and PTEN with forming phagosomes.

Pub. Date : 2007 Jul

PMID : 17442886






1 Functional Relationships(s)
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1 These results support a model in which phagosomal PI3K generates PI(3,4,5)P(3) necessary for later stages of phagocytosis, PTEN determines whether those late stages can occur, and SHIP-1 regulates when and where they occur by transiently suppressing PI(3,4,5)P(3)-dependent activities necessary for completion of phagocytosis. phosphoinositide-3,4,5-triphosphate inositol polyphosphate-5-phosphatase D Homo sapiens