Title : Transforming growth factor-beta 1 inhibits scavenger receptor activity in THP-1 human macrophages.

Pub. Date : 1991 Dec 5

PMID : 1744079






2 Functional Relationships(s)
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1 We now report that the induction of scavenger receptor activity (as measured by acetyl-LDL stimulation of intracellular cholesterol esterification) seen in phorbol ester-differentiated THP-1 human macrophages was completely suppressed to the level seen in undifferentiated THP-1 monocytes by picomolar concentrations of transforming growth factor-beta 1 (TGF-beta 1). Phorbol Esters transforming growth factor beta 1 Homo sapiens
2 We now report that the induction of scavenger receptor activity (as measured by acetyl-LDL stimulation of intracellular cholesterol esterification) seen in phorbol ester-differentiated THP-1 human macrophages was completely suppressed to the level seen in undifferentiated THP-1 monocytes by picomolar concentrations of transforming growth factor-beta 1 (TGF-beta 1). Phorbol Esters transforming growth factor beta 1 Homo sapiens