Title : SAG/ROC2/Rbx2 is a novel activator protein-1 target that promotes c-Jun degradation and inhibits 12-O-tetradecanoylphorbol-13-acetate-induced neoplastic transformation.

Pub. Date : 2007 Apr 15

PMID : 17440073






5 Functional Relationships(s)
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Protein Name
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1 Consistently, endogenous SAG is induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) with an induction time course following the c-Jun induction in both mouse epidermal JB6-Cl.41 and human 293 cells. sagopilone jun proto-oncogene Mus musculus
2 TPA-mediated SAG induction was significantly reduced in JB6-Cl.41 cells overexpressing a dominant-negative c-Jun, indicating a requirement of c-Jun/AP-1. sagopilone jun proto-oncogene Mus musculus
3 TPA-mediated SAG induction was significantly reduced in JB6-Cl.41 cells overexpressing a dominant-negative c-Jun, indicating a requirement of c-Jun/AP-1. sagopilone jun proto-oncogene Mus musculus
4 TPA-mediated SAG induction was significantly reduced in JB6-Cl.41 cells overexpressing a dominant-negative c-Jun, indicating a requirement of c-Jun/AP-1. sagopilone jun proto-oncogene Mus musculus
5 On the other hand, SAG seemed to modulate the c-Jun levels. sagopilone jun proto-oncogene Mus musculus