Pub. Date : 2007 Jun 1
PMID : 17434872
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lumiracoxib is the first example of a marketed COX-2 inhibitor of the arylacetic acid class, and it is reported to be the most selective COXIB in vivo. | lumiracoxib | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | Using standard assays, lumiracoxib was found to be a poor inhibitor of purified ovine COX-1 and a relatively weak inhibitor of purified human COX-2. | lumiracoxib | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 3 | Kinetic studies with lumiracoxib demonstrated that it was a time-dependent and slowly reversible inhibitor of human COX-2 that exhibited at least two binding steps during inhibition. | lumiracoxib | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 4 | Mutation of Ser-530 to Ala or Val-349 to Ala or Leu abolished the potent inhibition observed with wild-type human COX-2 and key lumiracoxib analogs. | lumiracoxib | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 5 | Taken together with a recent crystal structure of a lumiracoxib-COX-2 complex, the kinetic analyses presented herein of the inhibition of mutant COX-2s by lumiracoxib allows the definition of the molecular basis of COX-2 inhibition. | lumiracoxib | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 6 | Taken together with a recent crystal structure of a lumiracoxib-COX-2 complex, the kinetic analyses presented herein of the inhibition of mutant COX-2s by lumiracoxib allows the definition of the molecular basis of COX-2 inhibition. | lumiracoxib | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 7 | Taken together with a recent crystal structure of a lumiracoxib-COX-2 complex, the kinetic analyses presented herein of the inhibition of mutant COX-2s by lumiracoxib allows the definition of the molecular basis of COX-2 inhibition. | lumiracoxib | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 8 | Taken together with a recent crystal structure of a lumiracoxib-COX-2 complex, the kinetic analyses presented herein of the inhibition of mutant COX-2s by lumiracoxib allows the definition of the molecular basis of COX-2 inhibition. | lumiracoxib | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 9 | Taken together with a recent crystal structure of a lumiracoxib-COX-2 complex, the kinetic analyses presented herein of the inhibition of mutant COX-2s by lumiracoxib allows the definition of the molecular basis of COX-2 inhibition. | lumiracoxib | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 10 | Taken together with a recent crystal structure of a lumiracoxib-COX-2 complex, the kinetic analyses presented herein of the inhibition of mutant COX-2s by lumiracoxib allows the definition of the molecular basis of COX-2 inhibition. | lumiracoxib | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |