Title : Lesion specificity in the base excision repair enzyme hNeil1: modeling and dynamics studies.

Pub. Date : 2007 May 8

PMID : 17432829






1 Functional Relationships(s)
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1 The results of our investigations provide structural explanations for the ability of hNeil1 to excise a variety of oxidative lesions: they possess common chemical features, namely, a pyrimidine-like ring and shared hydrogen bond donor-acceptor properties, which allow the lesions to fit well in the binding pocket, which is somewhat flexible. pyrimidine nei like DNA glycosylase 1 Homo sapiens