Title : Inhibition of angiogenesis by the antifungal drug itraconazole.

Pub. Date : 2007 Apr 24

PMID : 17432820






2 Functional Relationships(s)
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1 In attempts to delineate the mechanism of action of itraconazole, we found that human lanosterol 14alpha-demethylase (14DM) is essential for endothelial cell proliferation and may partially mediate the inhibition of endothelial cells by itraconazole. Itraconazole cytochrome P450 family 51 subfamily A member 1 Homo sapiens
2 In attempts to delineate the mechanism of action of itraconazole, we found that human lanosterol 14alpha-demethylase (14DM) is essential for endothelial cell proliferation and may partially mediate the inhibition of endothelial cells by itraconazole. Itraconazole cytochrome P450 family 51 subfamily A member 1 Homo sapiens