Pub. Date : 2007 Mar
PMID : 17431384
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | AIM: This study was designed to investigate the role of COX-2 inhibitor nimesulide in cell growth and apoptosis of the cultured human hepatocellular carcinoma HepG2 cells. | nimesulide | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
2 | RESULTS: Our results showed that the treatment of HepG2 cells with more than 50 microM of nimesulide suppressed COX-2 enzyme activity because of reduced PGE(2) production, and then induced growth inhibition and cell apoptosis despite no alterations of COX-2 protein expression. | nimesulide | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
3 | RESULTS: Our results showed that the treatment of HepG2 cells with more than 50 microM of nimesulide suppressed COX-2 enzyme activity because of reduced PGE(2) production, and then induced growth inhibition and cell apoptosis despite no alterations of COX-2 protein expression. | nimesulide | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |