Title : Combination of cyclooxygenase-2 inhibitor and doxorubicin increases the growth inhibition and apoptosis in human hepatocellular carcinoma cells.

Pub. Date : 2007 Mar

PMID : 17431384






3 Functional Relationships(s)
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1 AIM: This study was designed to investigate the role of COX-2 inhibitor nimesulide in cell growth and apoptosis of the cultured human hepatocellular carcinoma HepG2 cells. nimesulide mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 RESULTS: Our results showed that the treatment of HepG2 cells with more than 50 microM of nimesulide suppressed COX-2 enzyme activity because of reduced PGE(2) production, and then induced growth inhibition and cell apoptosis despite no alterations of COX-2 protein expression. nimesulide mitochondrially encoded cytochrome c oxidase II Homo sapiens
3 RESULTS: Our results showed that the treatment of HepG2 cells with more than 50 microM of nimesulide suppressed COX-2 enzyme activity because of reduced PGE(2) production, and then induced growth inhibition and cell apoptosis despite no alterations of COX-2 protein expression. nimesulide mitochondrially encoded cytochrome c oxidase II Homo sapiens