Title : CYP1A induction and human risk assessment: an evolving tale of in vitro and in vivo studies.

Pub. Date : 2007 Jul

PMID : 17431034






3 Functional Relationships(s)
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1 CYP1A1 and 1A2 play critical roles in the metabolic activation of carcinogenic polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic amines/amides (HAAs), respectively, to electrophilic reactive intermediates, leading to toxicity and cancer. Polycyclic Aromatic Hydrocarbons cytochrome P450 family 1 subfamily A member 1 Homo sapiens
2 CYP1A1 and 1A2 play critical roles in the metabolic activation of carcinogenic polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic amines/amides (HAAs), respectively, to electrophilic reactive intermediates, leading to toxicity and cancer. Polycyclic Aromatic Hydrocarbons cytochrome P450 family 1 subfamily A member 1 Homo sapiens
3 CYP1As are highly inducible by PAHs and halogenated aromatic hydrocarbons via aryl hydrocarbon receptor-mediated gene transcription. Polycyclic Aromatic Hydrocarbons cytochrome P450 family 1 subfamily A member 1 Homo sapiens