Pub. Date : 2007 Jul
PMID : 17431031
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha. | Eicosanoids | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | Cytochrome P450 (P450) eicosanoids regulate vascular tone, renal tubular transport, cellular proliferation, and inflammation. | Eicosanoids | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | We show here that P450 eicosanoids can bind to and activate PPARalpha and result in the modulation of PPARalpha target gene expression. | Eicosanoids | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | In addition, P450 eicosanoids induced CYP4A1, sEH, and CYP2C11 expression, suggesting that they can regulate their own levels. | Eicosanoids | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 5 | Given that P450 eicosanoids have multiple cardiovascular effects, pharmacological modulation of their formation and/or degradation may yield therapeutic benefits. | Eicosanoids | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |