Title : The biochemical pharmacology of the thymidylate synthase inhibitor, 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).

Pub. Date : 1991 Oct 24

PMID : 1741766






2 Functional Relationships(s)
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1 The measurement of folylpolyglutamate synthetase (FPGS) substrate activity demonstrated a Km of 40 microM for ICI 198583 and a Vmax/Km (relative to folic acid) of 3.5. Folic Acid folylpolyglutamyl synthetase Mus musculus
2 The measurement of folylpolyglutamate synthetase (FPGS) substrate activity demonstrated a Km of 40 microM for ICI 198583 and a Vmax/Km (relative to folic acid) of 3.5. Folic Acid folylpolyglutamyl synthetase Mus musculus