Pub. Date : 2008 Mar
PMID : 17416370
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Compared with placebo, there was a significant dose-dependent decrease with rosuvastatin in plasma cholesterol, triglycerides, LDL cholesterol, apoB and apoC-III concentrations and in the apoB/apoA-I ratio, lathosterol:cholesterol ratio, HDL cholesterol concentration and campesterol:cholesterol ratio also increased significantly. | Rosuvastatin Calcium | apolipoprotein B | Homo sapiens |
| 2 | Rosuvastatin significantly increased the fractional catabolic rates (FCR) of very-low density lipoprotein (VLDL), intermediate density lipoprotein (IDL) and LDL-apoB and decreased the corresponding pool sizes, with evidence of a dose-related effect. | Rosuvastatin Calcium | apolipoprotein B | Homo sapiens |
| 3 | LDL apoB production rate (PR) fell significantly with rosuvastatin 40 mg/day with no change in VLDL and IDL-apoB PR. | Rosuvastatin Calcium | apolipoprotein B | Homo sapiens |
| 4 | In the metabolic syndrome, rosuvastatin decreases the plasma concentration of apoB-containing lipoproteins by a dose-dependent mechanism that increases their rates of catabolism. | Rosuvastatin Calcium | apolipoprotein B | Homo sapiens |
| 5 | Higher dose rosuvastatin may also decrease LDL apoB production. | Rosuvastatin Calcium | apolipoprotein B | Homo sapiens |