Pub. Date : 2007 Apr
PMID : 17409633
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Stearoyl-CoA desaturase activity is elevated by the suppression of its degradation by clofibric acid in the liver of rats. | Clofibric Acid | stearoyl-CoA desaturase | Rattus norvegicus |
| 2 | Treatment of rats with 2-(4-chlorophenoxy)-2-methylpropionic acid (clofibric acid) or feeding of a fat-free diet markedly elevated hepatic activity of SCD. | Clofibric Acid | stearoyl-CoA desaturase | Rattus norvegicus |
| 3 | Treatment of rats with 2-(4-chlorophenoxy)-2-methylpropionic acid (clofibric acid) or feeding of a fat-free diet markedly elevated hepatic activity of SCD. | Clofibric Acid | stearoyl-CoA desaturase | Rattus norvegicus |
| 4 | Both the treatment with clofibric acid and the feeding of the fat-free diet caused an increase in the steady-state level of SCD1 mRNA and enhanced transcriptional rate. | Clofibric Acid | stearoyl-CoA desaturase | Rattus norvegicus |
| 5 | The half-lives of SCD for control rats, rats treated with clofibric acid rats, and rats fed the fat-free diet were estimated to be 2.0, 3.9, and 1.9 h, respectively. | Clofibric Acid | stearoyl-CoA desaturase | Rattus norvegicus |
| 6 | Activity of palmitoyl-CoA chain elongase (PCE) was increased by both clofibric acid treatment and feeding of the fat-free diet as was observed with SCD. | Clofibric Acid | stearoyl-CoA desaturase | Rattus norvegicus |
| 7 | These results strongly suggest that the decreased degradation of SCD is responsible for the increase in its activity in addition to increased transcription of SCD1 in the rats treated with clofibric acid. | Clofibric Acid | stearoyl-CoA desaturase | Rattus norvegicus |
| 8 | These results strongly suggest that the decreased degradation of SCD is responsible for the increase in its activity in addition to increased transcription of SCD1 in the rats treated with clofibric acid. | Clofibric Acid | stearoyl-CoA desaturase | Rattus norvegicus |