Pub. Date : 2007 Apr 1
PMID : 17409429
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found that PD98059, which itself has minimal apoptogenic activity, acts synergistically with Nutlin-3a to induce apoptosis in wild-type p53 AML cell lines OCI-AML-3 and MOLM-13. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | tumor protein p53 | Homo sapiens |
| 2 | Interestingly, PD98059 enhanced nuclear proapototic function of p53 in these cells. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | tumor protein p53 | Homo sapiens |
| 3 | In accordance with the activation of transcription-dependent apoptosis, PD98059 treatment promoted the translocation of p53 from the cytoplasm to the nucleus in OCI-AML-3 cells, in which p53 primarily initiates transcription-independent apoptosis when cells are treated with Nutlin-3a alone. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | tumor protein p53 | Homo sapiens |
| 4 | In accordance with the activation of transcription-dependent apoptosis, PD98059 treatment promoted the translocation of p53 from the cytoplasm to the nucleus in OCI-AML-3 cells, in which p53 primarily initiates transcription-independent apoptosis when cells are treated with Nutlin-3a alone. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | tumor protein p53 | Homo sapiens |
| 5 | PD98059 prevented p53-mediated induction of p21 at the transcriptional level. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | tumor protein p53 | Homo sapiens |
| 6 | The repressed expression of antiapototic p21 also seemed to contribute to synergism between PD98059 and Nutlin-3a because (a) the synergistic apoptogenic effect was preserved in G(1) cells, (b) p53-mediated induction of p21 was preferentially seen in G(1) cells, (c) PD98059 strongly antagonized p21 induction by Nutlin-3a, and (d) cells with high p21 levels were resistant to apoptosis. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | tumor protein p53 | Homo sapiens |