Pub. Date : 2007 Jan-Feb
PMID : 17408061
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nifedipine, a calcium-channel blocker, inhibits advanced glycation end-product-induced expression of monocyte chemoattractant protein-1 in human cultured mesangial cells. | Nifedipine | C-C motif chemokine ligand 2 | Homo sapiens |
| 2 | This study investigated whether nifedipine, a widely used anti-hypertensive drug, suppresses expression of monocyte chemoattractant protein-1 (MCP-1), a chemokine that mediates the recruitment of monocytes to inflammatory sites, in AGE-exposed human cultured mesangial cells. | Nifedipine | C-C motif chemokine ligand 2 | Homo sapiens |
| 3 | This study investigated whether nifedipine, a widely used anti-hypertensive drug, suppresses expression of monocyte chemoattractant protein-1 (MCP-1), a chemokine that mediates the recruitment of monocytes to inflammatory sites, in AGE-exposed human cultured mesangial cells. | Nifedipine | C-C motif chemokine ligand 2 | Homo sapiens |
| 4 | AGEs significantly increased both MCP-1 mRNA expression and protein production in mesangial cells; this increase was blocked by both nifedipine and diphenylene iodonium. | Nifedipine | C-C motif chemokine ligand 2 | Homo sapiens |
| 5 | These results suggest that nifedipine could play a protective role against early diabetic nephropathy by suppressing MCP-1 overexpression via blockade of AGE signalling in mesangial cells. | Nifedipine | C-C motif chemokine ligand 2 | Homo sapiens |